Probes & Biosensors

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Tools for new labelling technologies, multi-modality imaging, label free...


Tony Gee, Alessandro Esposito, Gail McConnell, Erik Arstad, Nick Long, Ramon Vilar, Tony Ng, Tom Eykyn



The use of a wide array of imaging modalities has been invaluable for the advancement of the understanding of normo- and pathophysiology in animals, plants and humans both in vivo and in vitro. Many of these modalities rely on specific imaging probes to report on the biological status or obtain information about a particular bio-construct (eg. protein, receptor, enzyme) or bio-mechanism of interest. The detection of these molecules in the bio-mileu under investigation is based on target molecules being ‘tagged’ by imaging modality-dependent physicochemical ‘handles’ eg radioisotopes (PET/SPECT), chromophores/fluorophores (optical/fluorescence imaging), magnetically susceptible nuclei (NMR) or density (X-ray CT contrast agents).

Recent developments in the genomics, metabanomics and proteomics has led to the discovery of a plethora of new receptors enzymes, proteins which may play important, but as yet, unknown biological roles in heath and disease. However, at present there is a lack of corresponding imaging probes available to capitalise on these rapid advances. In order to align these imaging modalities with these recent advances a concerted effort will be required to developing the next generation of appropriate imaging biomarkers to ensure a productive future for biochemistry-related discovery in conjunction with these bioimaging platforms.


It is recommended that a network of experts in the area of imaging probe development be assembled to establish a critical mass of expertise with the aim to stimulate and create cross-laboratory national and European training / research programmes within this area (within and between modalities).

Membership, Expertise and Interests

Dr. Erik Arstad Dept Chemistry, University College, London

Prof. Nick Long Dept Chemistry, Imperial College, London

Prof. Antony Gee Division of Imaging Sciences and Bioengineering, King’s College London

Prof Tony Ng Randall Division of Cell and Molecular Biophysics, King’s College London

Prof Phil Blower Division of Imaging Sciences and Bioengineering, King’s College London

Peergroup Communication Resources

PET Special interest Group

PET Chemistry Community (via LinkedIn)


  • Jan 2011 Working Group Meeting Minutes
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